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- Title
Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women.
- Authors
Moslehi, Nazanin; Vafa, Mohammadreza; Rahimi-Foroushani, Abbas; Golestan, Banafsheh
- Abstract
Background: This study aimed to investigate whether magnesium supplementation might affect serum magnesium, high sensitive C-reactive protein (hs-CRP), plasma fibrinogen, and interleukin 6 (IL-6) levels in healthy middle-aged overweight women. The relationships, if any, between serum magnesium and the inflammatory markers were also examined cross-sectionally in the entire participants at the beginning of the study. Materials and Methods: This double-blinded, placebo-controlled, randomized trial included 74 middle-aged overweight women. Participants were randomly assigned to receive either 250 mg magnesium as magnesium oxide or placebo daily for 8 weeks. Serum magnesium, hs-CRP, fibrinogen and IL-6 concentrations were measured before and after the intervention. Results: Serum magnesium was found to be inversely correlated with hs-CRP (rs=−0.22, P=0.05) in the entire participants at baseline. Serum hs-CRP declined significantly in both groups as compared with baseline values (median change=0.8 mg/L; PMagnesium=0.03, PPlacebo<0.001). Plasma fibrinogen decreased significantly, by 9%, in the magnesium group at the end of week 8 compared to baseline (P=0.001). Mean concentration of IL-6 was significantly increased in the magnesium group comparing the baseline value(P=0.001). However hs-CRP, fibrinogen and IL-6 levels at week 8 or any changes during the study were not statistically different between the two groups. Serum magnesium showed no significant changes in any groups. Conclusions: Serum magnesium had a significant inverse correlation with hs-CRP. In the present study, magnesium as magnesium oxide, 250 mg/day, for 8 weeks did not significantly attenuate inflammatory markers in the magnesium group as compared to the placebo.
- Subjects
OBESITY complications; C-reactive protein; STATISTICAL correlation; DIETARY supplements; FIBRINOGEN; GOODNESS-of-fit tests; INFLAMMATION; INTERLEUKINS; MAGNESIUM; RESEARCH funding; STATISTICS; T-test (Statistics); STATISTICAL power analysis; DATA analysis; BODY mass index; RANDOMIZED controlled trials; BLIND experiment; DATA analysis software; MANN Whitney U Test
- Publication
Journal of Research in Medical Sciences, 2012, Vol 17, Issue 7, p607
- ISSN
1735-1995
- Publication type
Article