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- Title
Urinary Human Kidney Injury Molecule1- (hKIM1-) is not Increased in Patients with Renal Cell Carcinoma.
- Authors
Białek, Łukasz; Poletajew, Sławomir; Niemczyk, Michał; Czerwińska, Katarzyna; Nowak, Mateusz; Sadowska, Anna; Borkowski, Tomasz; Radziszewski, Piotr; Dobruch, Jakub; Kryst, Piotr; Bialek, Lukasz; Poletajew, Slawomir; Niemczyk, Michal; Czerwinska, Katarzyna
- Abstract
<bold>Purpose: </bold>Human Kidney Injury Molecule-1 (hKIM-1) was proposed as urinary biomarker of renal cell carcinoma (RCC). The aim of the study was to validate urinary hKIM-1 as a biomarker of RCC.<bold>Material and Methods: </bold>Forty-six participants were enrolled into the study, including 30 patients with clear-cell or papillary RCC and 16 matched patients in the comparison group. Preoperative urinary hKIM-1 levels were measured using commercially available ELISA kit and normalized to urinary creatinine levels.<bold>Results: </bold>The concentrations of urinary hKIM-1 normalized to urinary creatinine in patients with RCC and comparison group did not differ significantly (1.35 vs. 1.32 ng/mg creatinine, p=.25). There was also no difference in urinary hKIM-1 concentration regarding stage or grade of renal cancer. Additional analysis of patients without chronic kidney disease (defined as eGFR ≥60mL/min/1.73m²) also did not reveal significant difference in urinary hKIM-1 concentrations between the groups (1.54 vs. 1.37; p=.47).<bold>Conclusion: </bold>Results of our study do not confirm recent suggestions that urinary hKIM-1 may be a biomarker of RCC.
- Subjects
RENAL cell carcinoma; KIDNEY injuries; RENAL cancer; CHRONIC kidney failure; KIDNEY tumors; LONGITUDINAL method
- Publication
Urology Journal, 2020, Vol 17, Issue 6, p664
- ISSN
1735-1308
- Publication type
journal article
- DOI
10.22037/uj.v16i7.6077