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- Title
Catastrophic subarachnoid hemorrhage in eosinophilic granulomatosis with polyangiitis without asthma.
- Authors
Lee, Matilda X. W.; Teng, Gim Gee; Raju, Gangaraju Changal; Lim, Anita Y. N.
- Abstract
Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by eosinophilic vasculitis. Patients rarely present without asthma. Cases developing subarachnoid hemorrhage from central nervous system vasculitis are rarely reported. We report a 48‐year‐old woman with rapidly evolving and progressive multi‐system eosinophilic vasculitis in the absence of asthma. Tissue eosinophilia was apparent in a breast lump biopsy. Prior otitis media and prominent lymphoid tissue in the postnasal spaces hinted at otolaryngological disease. She had rapid disease progression with mononeuritis multiplex and eventually succumbed to complications of intracranial hemorrhage secondary to central nervous system vasculitis. This case demonstrates the diagnostic dilemma and treatment considerations in EGPA without asthma. It also raises the question if a reliable biomarker can aid diagnosis in atypical presentations of disease.
- Subjects
SUBARACHNOID hemorrhage; ASTHMA; VASCULITIS treatment; VASCULITIS; HEMORRHAGE; PATIENTS
- Publication
International Journal of Rheumatic Diseases, 2017, Vol 20, Issue 12, p2127
- ISSN
1756-1841
- Publication type
Article
- DOI
10.1111/1756-185X.12594