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- Title
Dissecting inhibitory brain circuits with genetically-targeted technologies.
- Authors
Murphey, Dona K.; Herman, Alexander M.; Arenkiel, Benjamin R.
- Abstract
The evolution of genetically targeted tools has begun to allow us to dissect anatomically and functionally heterogeneous interneurons, and to probe circuit function from synapses to behavior. Over the last decade, these tools have been used widely to visualize neurons in a cell type-specific manner, and engage them to activate and inactivate with exquisite precision. In this process, we have expanded our understanding of interneuron diversity, their functional connectivity, and how selective inhibitory circuits contribute to behavior. Here we discuss the relative assets of genetically encoded fluorescent proteins (FPs), viral tracing methods, optogenetics, chemical genetics, and biosensors in the study of inhibitory interneurons and their respective circuits.
- Subjects
PYRAMIDAL neurons; BRAIN tumors; HUMAN anatomy; CENTRAL nervous system; NERVOUS system
- Publication
Frontiers in Neural Circuits, 2014, Vol 8, p1
- ISSN
1662-5110
- Publication type
Article
- DOI
10.3389/fncir.2014.00124