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- Title
CAN HIGH URIC ACID LEVELS BE AN INDEPENDENT RISK FACTOR FOR ACUTE ISCHEMIC STROKE DUE TO LARGE-ARTERY ATHEROSCLEROSIS?
- Authors
ACAR, Türkan; GÜZEY ARAS, Yeşim; GÜL, Sıdıka Sinem; ACAR, Bilgehan Atılgan
- Abstract
Introduction – Uric acid is a molecule that is known to act as a natural antioxidant in acute oxidative stress conditions such as acute ischemic stroke (AIS). Although there are several studies on the prognostic value of serum uric acid (UA) level, especially the AIS, its importance in ischemic stroke is still controversial. Our aim in this study is to investigate whether the serum UA level is an indicative biomarker in the large-artery atherosclerosis in the AIS etiology. Material and method – Of the patients admitted to Sakarya University Training and Research Hospital Department of Neurology between January 2017 and November 2017, 91 hospitalized patients, who had AIS diagnosis and had their uric acid levels measured, were analyzed retrospectively. Patients with diabetes mellitus (DM), hypertension (HT), smoking habit, obesity, gout, hyperlipidemia (HL) and renal failure were excluded from the study. Patients were classified as anterior system and posterior system infarct. Then, patients were divided into two groups, one with internal carotid artery (ICA) > 50% stenosis and the other with ICA < 50% stenosis according to carotid-vertebral artery doppler USG examination performed for etiology. Serum UA, total bilirubin, direct bilirubin and indirect bilirubin levels of both groups were statistically compared. Results – In the comparison of serum UA values of ICA>50% stenosis and ICA0.05). Conclusion – High uric acid levels can be considered an independent, indicative risk factor for large-artery disease in AIS.
- Subjects
STROKE risk factors; URIC acid; ATHEROSCLEROSIS; BIOLOGICAL tags; BILIRUBIN; INTERNAL carotid artery
- Publication
Clinical Neuroscience / Ideggyógyászati Szemle, 2018, Vol 71, Issue 7/8, p279
- ISSN
0019-1442
- Publication type
Article
- DOI
10.18071/isz.71.0279