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- Title
Expression of receptor activator nuclear factor kappa B ligand and osteoprotegerin in peri-implant soft tissue and bone tissue.
- Authors
Zhou Wenjuan; Liu Zhonghao; Xu Sheng; Hao Pengjie; Xu Fengwei; Sun Aijie; Lu Zhishan
- Abstract
Objective To study niRNA expression of receptor activator nuclear factor kappa B ligand (RANKL) and its decoy receptor, osteoprotegerin (OPG) in peri-implant tissue during unloading period. Methods An animal model of dental implant was established in 6 male Beagle dogs of 1-2 years old. Bone remodeling was tested at 3, 7, 15, 30, 60 and 90 days since the placement of implants. RANKL and OPG mRNA expression were quantified by real-time polymerase chain reaction (PCR). Then mandibular bones were taken out and the morphological changes were observed by X-ray, bone tissue was tested by immunohistochemistry stain. Results The most prominent period of bone remode-ling occurred at 7th day after the placement of implants. The expression of RANKL and OPG increased in a time-dependent manner in both soft and hard tissue. After 7 days they gradually decreased. Conclusion RANKL and OPG can express in soft tissue, and the changing tendency is consistent with the change of bone remodeling, it indicates that RANKL and OPG play an important role in the bone remodeling.
- Publication
West China Journal of Stomatology, 2012, Vol 30, Issue 1, p25
- ISSN
1000-1182
- Publication type
Article
- DOI
10.3969/j.issn.1000-1182.2012.01.006