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- Title
ČIMBENICI RIZIKA POJAVNOSTI METASTAZA U LIMFNIM ČVOROVIMA NEČUVARIMA U RANOM STADIJU KARCINOMA DOJKE.
- Authors
Gembić, Tihana Klarica; Grebić, Damir; Gulić, Tamara; Kustić, Domagoj; Nekić, Jasna; KNEŽEVIĆ, SARA BILIĆ
- Abstract
Introduction: Sentinel lymph node biopsy (SLNB) has become an established standard of care in the management of early-stage clinically node-negative breast cancer (BC). Most SLN-positive BC patients do not have additional axillary lymph node (ALN) metastasis and would not benefit from further ALN dissection (ALND). This study aims to identify the risk factors for non-SLN metastasis in BC patients with limited SLN involvement, as well as the prognostic role of non-SLN metastasis on 5-year overall, locoregional recurrence-free, distant recurrence-free, and disease-specific-free survival (OS, LRFS, DRFS, and DFS, respectively). Methods: We retrospectively included 275 patients with early-stage invasive BC with positive SLNB followed by ALND at our institution between 2007 and 2016. Preceding SLNB, each patient underwent SLN scintigraphy using [99mTc] Tc-nanocolloid. Results: Of 275 patients, 96 (34.91%) had non-SLN metastasis. The results of the multivariate analysis showed that extra nodal extension (ENE) in SLN (OR 5.60, CI 2.66–11.77, P<0.001), histological grade (OR 2.08, CI 1.19–3.64, P=0.010), tumor size (OR 1.38, CI 1.02–1.86, P=0.037) and size of SLN metastasis (OR 1.11, CI 1.05– 1.17, P<0.001) were the independent risk factors for non-SLN metastasis. Patients with non-SLN metastasis had worse 5-year OS (P<0.001), LRFS (P=0.038), DRFS (P<0.001), and DFS (P<0.001), respectively. Conclusion: ENE in SLN, histological grade, tumor size, and size of SLN metastasis were associated with a high risk of non-SLN metastasis, which has a significant impact on BC survival. Therefore, we suggest considering these factors in BC treatment planning and follow-up.
- Publication
Lijecnicki Vjesnik, 2023, Vol 145, p36
- ISSN
0024-3477
- Publication type
Article
- DOI
10.26800/LV-145-supl6-2