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- Title
Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient.
- Authors
Andonov, Anton; Robbins, Mark; Borlang, Jamie; Cao, Jingxin; Hatchette, Todd; Stueck, Ashley; Deschambault, Yvon; Murnaghan, Kyle; Varga, Jessy; Johnston, Lynn
- Abstract
Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.
- Subjects
HEPATITIS E virus; HEPATITIS; RATS; WATER pollution; U.S. states; ANIMAL experimentation; COMPARATIVE studies; BIOLOGICAL evolution; GENOMES; HEPATITIS E; HEPATITIS viruses; IMMUNE response; IMMUNOCOMPETENT cells; IMMUNOGLOBULINS; LIVER; RESEARCH methodology; MEDICAL cooperation; RESEARCH; VIRAL antibodies; ZOONOSES; EVALUATION research; INFECTIOUS disease transmission
- Publication
Journal of Infectious Diseases, 2019, Vol 220, Issue 6, p951
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiz025