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- Title
Protective Effectiveness of Inactivated Hantavirus Vaccine Against Hemorrhagic Fever With Renal Syndrome.
- Authors
Jaehun Jung; Sung-Jun Ko; Hong Sang Oh; Song Mi Moon; Jin-Won Song; Kyungmin Huh; Jung, Jaehun; Ko, Sung-Jun; Oh, Hong Sang; Moon, Song Mi; Song, Jin-Won; Huh, Kyungmin
- Abstract
As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.
- Subjects
HANTAVIRUS diseases; HEMORRHAGIC fever; DISEASE incidence; VACCINE effectiveness; ARENAVIRUS diseases; VACCINATION
- Publication
Journal of Infectious Diseases, 2018, Vol 217, Issue 9, p1417
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiy037