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- Title
Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study.
- Authors
Pierce Campbell, Christine M.; Viscidi, Raphael P.; Torres, B. Nelson; Hui-Yi Lin; Fulp, William; Abrahamsen, Martha; Lazcano-Ponce, Eduardo; Villa, Luisa L.; Kreimer, Aimée R.; Giuliano, Anna R.; Lin, Hui-Yi
- Abstract
The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval, .56-4.76).
- Subjects
BRAZIL; MEXICO; UNITED States; CD4 antigen; HERPES simplex virus; T cells; SKIN diseases; HERPES genitalis; TRANSMISSION of papillomavirus diseases; LONGITUDINAL method; PAPILLOMAVIRUS diseases; PAPILLOMAVIRUSES; RESEARCH funding; RISK assessment; VIRAL antibodies; PROPORTIONAL hazards models; OROPHARYNGEAL cancer; DISEASE complications
- Publication
Journal of Infectious Diseases, 2016, Vol 214, Issue 1, p45
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiw083