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- Title
Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation.
- Authors
Panikkar, Archana; Smith, Corey; Hislop, Andrew; Tellam, Nick; Dasari, Vijayendra; Hogquist, Kristin A.; Wykes, Michelle; Moss, Denis J.; Rickinson, Alan; Balfour Jr, Henry H.; Khanna, Rajiv; Balfour, Henry H Jr
- Abstract
Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM.
- Subjects
DENDRITIC cells; CYTOKINES; MONONUCLEOSIS; T cells; HOMEOSTASIS; INTERLEUKIN-10; HERPESVIRUSES; BLOOD cells; CELL physiology; IMMUNOLOGICAL tolerance; INTERLEUKINS; RESEARCH funding
- Publication
Journal of Infectious Diseases, 2015, Vol 212, Issue 12, p1957
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv340