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- Title
An Important Role of Prostanoid Receptor EP2 in Host Resistance to Mycobacterium tuberculosis Infection in Mice.
- Authors
Kaul, Vandana; Bhattacharya, Debapriya; Singh, Yogesh; Van Kaer, Luc; Peters-Golden, Marc; Bishai, William R; Das, Gobardhan
- Abstract
Mycobacterium tuberculosis, the causative agent of tuberculosis, resides and replicates within susceptible hosts by inhibiting host antimicrobial mechanisms. Prostaglandin E2 (PGE2), produced by M. tuberculosis–infected macrophages, exerts a variety of immunomodulatory functions via 4 receptors (EP1–EP4), each mediating distinct PGE2 functions. Here, we show that M. tuberculosis infection selectively upregulates EP2 messenger RNA expression in CD4+ T cells. We found that EP2 deficiency in mice increases susceptibility to M. tuberculosis infection, which correlated with reduced antigen-specific T-cell responses and increased levels of CD4+CD25+Foxp3+ T-regulatory cells. These findings have revealed an important role for EP2 in host immune defense against tuberculosis. As a G protein-coupled receptor, EP2 could serve as a target for immunotherapy of tuberculosis.
- Subjects
MYCOBACTERIUM tuberculosis; PROSTANOIDS; NATURAL immunity; LABORATORY mice; ANTI-infective agents; IMMUNOMODULATORS; TUBERCULOSIS treatment
- Publication
Journal of Infectious Diseases, 2012, Vol 206, Issue 12, p1816
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jis609