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- Title
Parvovirus 4 infection and clinical outcome in high-risk populations.
- Authors
Simmons R; Sharp C; McClure CP; Rohrbach J; Kovari H; Frangou E; Simmonds P; Irving W; Rauch A; Bowness P; Klenerman P; Swiss HIV Cohort Study; Simmons, Ruth; Sharp, Colin; McClure, C Patrick; Rohrbach, Janine; Kovari, Helen; Frangou, Eleni; Simmonds, Peter; Irving, Will
- Abstract
Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.
- Publication
Journal of Infectious Diseases, 2012, Vol 205, Issue 12, p1816
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jis291