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- Title
FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling
- Authors
Ahn, Hee-Jin; Lee, Woo-Jung; Kwack, KyuBum; Kwon, Young Do
- Abstract
Abstract: FGF2 has been shown to enhance proliferation and maintain differentiation potential in hMSCs during in vitro propagation. In this study, we investigated the role of mitogen-activated protein kinase in the functions of FGF2 in hMSCs. We demonstrated that FGF2 induces the transient activation of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated protein kinase or p38 protein kinase. SP600125 and a dominant negative JNK1 significantly reduced the FGF2-enhanced proliferation of hMSCs. Treatment with SP600125 also diminished the activity of FGF2 in the maintenance of adipogenic and osteogenic differentiation potential. These results suggest that JNK signaling is involved in the FGF2-induced stimulation of the proliferation and the maintenance of differentiation potential in hMSCs.
- Subjects
FIBROBLAST growth factors; CELL proliferation; CELL differentiation; STEM cells; MITOGEN-activated protein kinases; CELLULAR signal transduction; PROTEIN kinases
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2922
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.07.056