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- Title
Rapid down-regulation of mitochondrial fat metabolism in human muscle after training cessation is dissociated from changes in insulin sensitivity
- Authors
Rimbert, Virginie; Vidal, Hubert; Duché, Pascale; Debard, Cyrille; Giraudet, Christophe; Boirie, Yves; Chardigny, Jean-Michel; Morio, Béatrice
- Abstract
Abstract: The association between impairment in mitochondrial muscle fat oxidative capacity (OXFA) and occurrence of insulin resistance was examined in 14 healthy trained men (age, 24±4yr) submitted to 4weeks of training cessation. Training stop induced a significant decrease in mRNA levels of proteins involved in muscle fat metabolism, particularly PPARα (−58%, P <0.01) and PGC-1α (−30%, P <0.05), a 21% reduction in OXFA (P <0.01), and reduced fat oxidation during moderately intense exercise (P <0.05). In contrast, there was no significant alteration in insulin sensitivity. In conclusion, decline in OXFA is a rapid metabolic event following training cessation. It is involved in the regulation of whole body fat balance but not in the deterioration of insulin sensitivity.
- Subjects
METABOLISM; FAT; INSULIN resistance; MESSENGER RNA; BODY mass index; METABOLIC syndrome; MITOCHONDRIA; MUSCLES
- Publication
FEBS Letters, 2009, Vol 583, Issue 17, p2927
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.07.059