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- Title
Interferon gamma-dependent transactivation of epidermal growth factor receptor
- Authors
Burova, Elena; Vassilenko, Konstantin; Dorosh, Victoria; Gonchar, Ilya; Nikolsky, Nikolai
- Abstract
Abstract: The present report provides evidence that, in A431 cells, interferon γ (IFNγ) induces the rapid (within 5min), and reversible, tyrosine phosphorylation of the epidermal growth factor receptor (EGFR). IFNγ-induced EGFR transactivation requires EGFR kinase activity, as well as activity of the Src-family tyrosine kinases and JAK2. Here, we show that IFNγ-induced STAT1 activation in A431 and HeLa cells partially depends on the kinase activity of both EGFR and Src. Furthermore, in these cells, EGFR kinase activity is essential for IFNγ-induced ERK1,2 activation. This study is the first to demonstrate that EGFR is implicated in IFNγ-dependent signaling pathways.
- Subjects
EPIDERMAL growth factor; GROWTH factors; CYTOKINES; PEPTIDES
- Publication
FEBS Letters, 2007, Vol 581, Issue 7, p1475
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.03.002