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- Title
The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
- Authors
Boxem, Mike; Tsai, Chiawei W.; Zhang, Yi; Saito, R. Mako; Liu, Jun O.
- Abstract
We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner.
- Subjects
INFERTILITY; CELL proliferation; GENETICS; GENOMES
- Publication
FEBS Letters, 2004, Vol 576, Issue 1/2, p245
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2004.08.077