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- Title
Whole blood gene expression profiling distinguishes systemic sclerosis‐overlap syndromes from other subsets.
- Authors
Moinzadeh, P.; Frommolt, P.; Franitza, M.; Toliat, M. R.; Becker, K.; Nürnberg, P.; Nihtyanova, S. I.; Ahrazoglu, M.; Belz, D.; Hunzelmann, N.; Abraham, D.; Ong, V. H.; Mouthon, L.; Hesselstrand, R.; Denton, C. P.; Krieg, T.
- Abstract
Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets Among autoimmune rheumatic diseases, systemic sclerosis (SSc) is especially challenging due to its clinical diversity, reflected by the extent of skin and internal organ involvement.[1] Besides the two major subsets, limited and diffuse SSc (lcSSc and dcSSc), a substantial number of SSc cases exhibit overlap features of another rheumatic disease, summarized as SSc-overlap syndromes. Whole blood of 150 SSc patients (86 patients classified as dcSSc or lcSSc, and 64 as SSc-overlap syndromes) and 40 HC, collected at four different European centres, has been used.
- Subjects
GENE expression profiling; SCLERODERMA (Disease)
- Publication
Journal of the European Academy of Dermatology & Venereology, 2020, Vol 34, Issue 5, pe236
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/jdv.16198