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- Title
Prognostic value of cardiac I-123 metaiodobenzylguanidine imaging in patients with non–insulin-dependent diabetes mellitus
- Authors
Nagamachi, Shigeki; Fujita, Seigo; Nishii, Ryuichi; Futami, Shigemi; Tamura, Shozo; Mizuta, Masanari; Nakazato, Masamitsu; Kurose, Takeshi; Wakamatsu, Hideyuki
- Abstract
<bold>Background: </bold>123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is a useful tool for diagnosing cardiac autonomic neuropathy (CAN) in non-insulin-dependent diabetes mellitus (NIDDM). However, the long-term prognostic value for cardiac events or mortality in NIDDM has not been clarified.<bold>Methods and Results: </bold>We investigated the long-term prognostic value of cardiac MIBG imaging for both cardiac event and mortality owing to a variety of causes of death in NIDDM. 144 NIDDM patients were analyzed retrospectively with the end-points of a cardiac event and various causes of mortality. The heart-to-mediastinum uptake ratio on the delayed image (H/M [d]) was obtained from anterior planar imaging. The mean follow-up period was 7.2+/-3.2 years. Seventeen patients had a cardiac event onset and 7 patients died during observation. During the same observation course, 16 patients died, including some who died of cardiac event. Both multivariate and univariate analyses revealed that decreased H/M (d) (<1.7) was the independent predictor of long-term mortality for a variety of causes of death. Although the value of H/M (d) was not a significant prognostic factor for predicting a cardiac event, CAN, diagnosed by a combination of H/M (d) and coefficient variance of RR interval, was an independent predictor for the cardiac event in NIDDM.<bold>Conclusion: </bold>MIBG myocardial scintigraphy was useful for predicting cardiac events and long-term mortality in NIDDM.
- Subjects
HEART diseases; DIABETES; NEUROPATHY; POSITRON emission tomography
- Publication
Journal of Nuclear Cardiology, 2006, Vol 13, Issue 1, p34
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1016/j.nuclcard.2005.11.009