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- Title
Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis.
- Authors
Seyyedi, Javad; Alizadeh, Shahab
- Abstract
Background: This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Methods: PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies. Results: A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = − 58.91; 95%CI (confidence interval), − 77.10 to − 40.72; P = ˂ 0.001), ICAM-1 (WMD = − 36.58; 95%CI, − 49.65 to − 23.52; P = ˂ 0.001), and E-selectin (WMD = − 11.22; 95%CI, − 14.43 to − 8.01; P < 0.001), but had no significant effect on VCAM-1. Conclusion: Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
- Subjects
ENDOTHELIUM diseases; CD54 antigen; CELL adhesion molecules; META-analysis; BARIATRIC surgery
- Publication
Obesity Surgery, 2020, Vol 30, Issue 9, p3549
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-020-04710-1