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- Title
Changes in renal function during weight loss induced by high vs low-protein low-fat diets in overweight subjects.
- Authors
Rosenvinge Skov, A; Toubro, S; Bülow, J; Krabbe, K; Parving, H-H; Astrup, A
- Abstract
BACKGROUND: Due to the high satiating effect of protein, a high-protein diet may be desirable in the treatment of obesity. However the long-term effect of different levels of protein intake on renal function is unclear. OBJECTIVE: To assess the renal effects of high vs Iow protein contents in fat-reduced diets. DESIGN: Randomized 6 months dietary intervention study comparing two controlled adlibitum diets with 30 energy (E%) fat content: high-protein (HP; 25 E%) or Iow-protein, (LP, 12 E% protein). All food was provided by self-selection in a shop at the department, and high compliance to the diet composition was confirmed by measurements of urinary nitrogen excretion. SUBJECTS: 65 healthy, overweight and obese (25 < body mass index (BMI) < 34 kg/m²). RESULTS: Dietary protein intake changed from 91.1 g/d to a 6 months intervention average of 70.4 g/d (P < 0.05) in the LP group and from 91.4 g/d to 107.8 g/d (P < 0.05) in the HP group, producing changes in glomular filtration rate (GFR) of - 7.1 ml/min in the LP group and + 5.2 ml/min in the HP group (group effect: P < 0.05). Kidney volume decreased by - 6.2cm³ in the LP group and increased by Jr 9.1 cm³ in the HP group (P < 0.05), whereas albuminuria remained unchanged in all groups. CONCLUSION: Moderate changes in dietary protein intake cause adaptive alterations in renal size and function without indications of adverse effects.
- Subjects
DIETARY proteins; GLOMERULAR filtration rate; OBESITY
- Publication
International Journal of Obesity & Related Metabolic Disorders, 1999, Vol 23, Issue 11, p1170
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801048