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- Title
Overexpression of Cyclooxygenase-2 and Transforming Growth Factor-Beta 1 is an Independent Predictor of Poor Virological Response to Interferon Therapy in Chronic HCV Genotype 4 Patients.
- Authors
Gomaa, Wafaey M.; Ibrahim, Mohammed A.; Shatat, Mohamed E.
- Abstract
Background/Aims: COX-2 and TGF-β1 are overexpressed in hepatitis C virus (HCV) infection and are related to hepatitis pathogenesis and hepatic fibrosis. The current study investigated the relationship between pretreatment COX-2 and TGF-β1 hepatic expression in HCV genotype 4 and the virological response to interferon therapy. Patients and Methods: Liver biopsies of 55 patients with HCV infection genotype 4 were selected together with 10 liver biopsies as control. The patients' clinicopathological data were collected. Immunohistochemistry was done using anti-COX-2 and anti-TGF-β1 antibodies. Statistical tests were used to determine the association between both COX-2 and TGF-β1 expression in relation to clinicopathological parameters and response to interferon therapy. Results: COX-2 was upregulated especially in nonresponders and was an independent predictor of poor virological response. However, COX-2 showed no association with other clinicopathological features. TGF-β1 was upregulated and associated with nonresponders, histological activity, and fibrosis stage. There was no association between TGF-β1 and other clinicopathological features. There was an association between COX-2 and TGF-β1 immunoexpression. Conclusion: Overexpression of COX-2 and TGF-β1 is an independent predictor for poor outcome of interferon and ribavirin therapy and these might be useful markers for the response to treatment. Both molecules are associated together; however, their role during hepatitis treatment has to be clarified.
- Subjects
SAUDI Arabia; THERAPEUTIC use of interferons; ACADEMIC medical centers; BIOPSY; BLOOD testing; CELL receptors; CONFIDENCE intervals; STATISTICAL correlation; CYTOKINES; EPIDEMIOLOGY; GENES; HEPATITIS C; IMMUNOHISTOCHEMISTRY; LIVER; POLYMERASE chain reaction; PROGNOSIS; STATISTICS; U-statistics; LOGISTIC regression analysis; DATA analysis; FIBROSIS; DATA analysis software; DESCRIPTIVE statistics
- Publication
Saudi Journal of Gastroenterology, 2014, Vol 20, Issue 1, p59
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.126324