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- Title
Monoclonal Antibody against T-Cell Receptor α β Induces Self-Tolerance in Chronic Experimental Autoimmune Encephalomyelitis.
- Authors
Lavasani, S.; Dzhambazov, B.; Andersson, M.
- Abstract
The therapeutic effect of monoclonal antibody (H57-597 MoAb) against T-cell receptor (TCR) α β has been investigated on MOG35−55-induced experimental autoimmune encephalomyelitis (EAE), as a model system for T-cell-mediated chronic inflammation in the central nervous system (CNS). Short-term administration of the anti-TCR α β immediately after immunization protected the mice from EAE. Furthermore, anti-TCR α β treatment on an established disease restored the self-tolerance which led to a complete remission of EAE and a dramatic reduction of inflammatory cells in the CNS, while treatment with control antibody (hamster IgG) was ineffective. The remission was durable and not associated with disappearance of autoreactive T cells as measured by persistence of MOG-reactive T-cell proliferation in vitro. However, MOG-reactive T cells from anti-TCR-treated animals produced significantly lower amounts of inflammatory TNF- α and IFN- γ. In addition, while a transient deletion of CD4+ and CD8+ T cells was observed, a population of T cells expressing CD3, NK1.1 and CD69 (NKT cells) were expanding. By transfer of spleen cells from anti-TCR MoAb-treated animals, we could show that the tolerogenic capacity can be transferred to untreated recipients with EAE. The data indicate therapeutic effect of anti-TCR α β MoAb (H57-597), which represents a promising approach in treatment of T-cell-mediated autoimmune diseases.
- Subjects
MONOCLONAL antibodies; CENTRAL nervous system diseases; ENCEPHALOMYELITIS; T cell receptors; AUTOIMMUNE diseases; IMMUNOLOGIC diseases
- Publication
Scandinavian Journal of Immunology, 2007, Vol 65, Issue 1, p39
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2006.01866.x