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- Title
Increased Hepatocyte Fas Expression and Apoptosis in HIV and Hepatitis C Virus Coinfection.
- Authors
Macías, Juan; Japón, Miguel A.; Sáez, Carmen; Palacios, Rosa B.; Mira, José A.; García-García, José A.; Merchante, Nicolás; Vergara, Salvador; Lozano, Fernando; Gómez-Mateos, Jesús; Pineda, Juan A.
- Abstract
Background. Chronic hepatitis C disease (CHC) follows an accelerated course in human immunodeficiency virus (HIV) coinfection. The reasons for this are uncle at Fas-mediated hepatocyte apoptosis is involved in the pathogenesis of hepatitis C virus (HCV) infection. We sought to compare the expression of Fas on hepatocytes and irreversible apoptosis of hepatocytes among patients with CHC with and without HCV/HIV coinfection. Methods. Fas-immunostained hepatocytes were semiquantified, and apoptotic hepatocytes were detected by staining caspase-cleaved cytokeratin 18 filaments and counted across the entire section of liver-biopsy specimens from HCV-infected patients with and without HCV/HIV coinfection. Results. One hundred thirty-four HCV/HIV-coinfected and 100 HCV-infected patients were included. HCV/ HIV coinfection was associated with both diffuse distribution of Fas-stained hepatocytes (adjusted odds ratio [AOR], 7.4 [95% confidence interval {CI}, 3.8-14.4]) and with apoptotic hepatocyte counts greater than the median (AOR, 2.5 [95% CI, 1.5-4.5]). In HCV/HIV-coinfected patients, CD4+ cell nadir <200 cells/mL was associated with both Fas expression (AOR, 2.9 [95% CI, 1.3-6.8]) and hepatocyte apoptosis (AOR, 2.3 [95% CI, 1.1-4.9]). Conclusion. HCV/HIV-coinfected patients show higher levels of hepatocytes expressing Fas and undergoing irreversible apoptosis than do HCV-infected patients. However, low CD4+ cell nadirs in coinfected patients are associated with hepatocyte Fas expression and apoptosis.
- Subjects
HEPATOCYTE growth factor; APOPTOSIS; HIV; HIV infections; VIRAL hepatitis; CELL death
- Publication
Journal of Infectious Diseases, 2005, Vol 192, Issue 9, p1566
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/491736