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- Title
Staphylococcus aureus menD and hemB Mutants Are as Infective as the Parent Strains, but the Menadione Biosynthetic Mutant Persists within the Kidney.
- Authors
Bates, Donna M.; von Eiff, Christof; McNamara, Peter J.; Peters, Georg; Yeaman, Michael R.; Bayer, Arnold S.; Proctor, Richard A.
- Abstract
Discusses the generation of small colony variants (SCV) of Staphylococcus aureus via mutations in menD or hemB. Menadione and hemin auxotrophs yielded; Ability of SCV to colonize multiple tissues in vivo; MenD mutation's provision of the organism with a survival advantage during antimicrobial therapy.
- Subjects
STAPHYLOCOCCUS aureus; GENETIC mutation
- Publication
Journal of Infectious Diseases, 2003, Vol 187, Issue 10, p1654
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/374642