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- Title
Autologous Fat Grafting for Treatment of Breast Implant Capsular Contracture: A Study in Pigs.
- Authors
Roça, Guilherme Berto; Graf, Ruth; da Silva Freitas, Renato; Salles, Guataçara; Francisco, Julio Cesar; Noronha, Lucia; Maluf, Ivan; Roça, Guilherme Berto; Salles, Guataçara Jr; Maluf, Ivan Jr
- Abstract
<bold>Background: </bold>Capsular contracture (CC) is a common complication after breast augmentation. Autologous fat grafting may be effective for restoring tissue vascularization and function.<bold>Objective: </bold>The authors evaluated the efficacy of autologous fat grafting in a porcine model as a treatment for CC after breast augmentation.<bold>Methods: </bold>This prospective study was performed in 20 female 30-day-old pigs. Each animal was implanted with three 30-cc textured silicone implants (stage 1 of the experiment). Group A served as the untreated control group. To induce CC, 2 mL of autologous fibrin glue was applied to the pericapsular space in group B and C animals at implantation. Three months after implantation (stage 2), the CCs of all groups were assessed by Baker classification and applanation tonometry (AT). Liposuction was performed in group B to harvest fat for these animals. Three months after group B underwent fat grafting, all 3 groups were reevaluated. Reassessments included Baker classification, AT, histologic analysis, and tensiometry (stage 3).<bold>Results: </bold>The deposition of mature and immature collagen was similar for the 3 groups. The amount of fat remaining around the implanted capsules did not differ significantly between the groups. At stage 3, group B exhibited significantly larger tonometry areas than did group C. The CCs in groups B and C were significantly thicker than those of group A, but the difference between groups B and C was not significant. Capsule rupture forces did not differ significantly between groups A and B but were significantly higher in group C compared with the other groups.<bold>Conclusions: </bold>Results in this animal model indicate that pericapsular lipoinjection may be a promising treatment for CC in humans.
- Subjects
ADIPOSE tissue transplantation; ANIMAL experimentation; ANIMALS; AUTOGRAFTS; BIOLOGICAL models; BREAST implants; SILICONES; SWINE; TIME; FOREIGN body reaction; DIAGNOSIS; EQUIPMENT &; supplies
- Publication
Aesthetic Surgery Journal, 2014, Vol 34, Issue 5, p769
- ISSN
1090-820X
- Publication type
journal article
- DOI
10.1177/1090820X14533184