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- Title
Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome.
- Authors
Pagano, Miguel A.; Segura, Martín J.; Di Lorenzo, Guillermo A.; Garau, María L.; Molina, Hugo A.; Cahn, Pedro; Perez, Héctor; Vítolo, Fabián; Grondona, Alba; Piedimonte, Fabián C.; Giannaula, Rolando; Ramia, Raúl; Miranda, Miguel A.; Sierra, Hernán; Sica, Roberto E. P.; Pagano, M A; Segura, M J; Di Lorenzo, G A; Garau, M L; Molina, H A
- Abstract
Cerebral tumor-like American trypanosomiasis (CTLAT) is an uncommon complication of Chagas' disease, observed only in immunosuppressed patients. We assessed 10 human immunodeficiency virus-positive patients with Chagas' disease who presented with CTLAT. All patients had neurological involvement and 6 developed intracranial hypertension. Neuroimaging studies showed supratentorial lesions in 9 patients, being single in 8. One case had infratentorial and supratentorial lesions. Low CD4+ cell counts were observed in all the cases and in 6 of them CTLAT was the first manifestation of acquired immunodeficiency syndrome. Serological tests for Chagas' disease were positive in 6 of 8 patients. Trypanosoma cruzi was identified in all brain specimens and in three cerebrospinal fluid samples. CTLAT should be considered in the differential diagnosis of intracranial mass lesions in human immunodeficiency virus-positive patients and should be added to the list of acquired immunodeficiency syndrome-defining illnesses.
- Publication
Annals of Neurology, 1999, Vol 45, Issue 3, p403
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/1531-8249(199903)45:3<403::AID-ANA20>3.0.CO;2-K