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- Title
Metalloenzymes: Natural product nitrosation.
- Authors
Kersten, Roland D; Dorrestein, Pieter C
- Abstract
The article presents the author's insights on the study which centers on the biosynthetic pathway to the natural product 4-hydroxy-3-nitrosobenzamide from Streptomyces murayamaensis. It mentions that the biosynthetic genes were identified based from the theory that similar enzymes were responsible on the creation of the 3-amino-4-hydroxybenzoic acid, found in the 4,3-HNBAm pathway. It adds that the study has identified C-nitrosynthase with copper that regulates oxidation in aromatic amine.
- Subjects
NITROSATION; NITROSAMIDES; BIOSYNTHESIS; STREPTOMYCES; COPPER; OXIDATION; AROMATIC amines
- Publication
Nature Chemical Biology, 2010, Vol 6, Issue 9, p636
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.425