We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical decay of an antibiotic inverts selection for resistance.
- Authors
Palmer, Adam C.; Angelino, Elaine; Kishony, Roy
- Abstract
Antibiotics are often unstable and can decay into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes but actually reverses to become a prolonged disadvantage due to the activities of more stable degradation products. Tetracycline decay can lead to net selection against resistance, which may help explain the puzzling coexistence of sensitive and resistant strains in natural environments.
- Subjects
ANTIBIOTICS; ANTI-infective agents; TETRACYCLINE; SULFAGUANIDINE; THERAPEUTICS
- Publication
Nature Chemical Biology, 2010, Vol 6, Issue 2, p105
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.289