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- Title
Superficial Hemosiderotic Angiomyxoma.
- Authors
Trotter, Martin J.; O'Connell, John X.; Tron, Victor A.
- Abstract
A case of superficial angiomyxoma presenting as a pigmented nevus on the shoulder of a 77-year-old man is described. Histologically, the lesion was unencapsulated and demonstrated numerous small, bland, bipolar spindle cells embedded in a vascular, mucinous stroma. The lesion was also characterized by extensive, perivascular collections of large macrophages with foamy cytoplasm and extensive intracellular deposition of granular, golden-brown pigment consistent with hemosiderin. The iron stain was strongly positive. These phagocytic cells stained positively for vimentin and Ham 56, supporting a macrophage lineage. Hemosiderin was also noted within the cytoplasm of the spindle cells in the angiomyxomatous component; these spindle cells expressed factor XIIIa, CD34, or both, and thus likely represented dermal dendritic cells with phagocytic properties. Numerous hemosiderin-laden macrophages in cutaneous angiomyxoma, possibly a result of occult trauma, result in a distinctive histologic appearance and may result in clinical resemblance to a melanocytic nevus.
- Subjects
MYXOMA; PIGMENTS; NEVUS; HEMOSIDERIN; MACROPHAGES; SPINDLE apparatus
- Publication
International Journal of Surgical Pathology, 1996, Vol 4, Issue 2, p83
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/106689699600400204