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- Title
Green tea modulates reserpine toxicity in animal models.
- Authors
Al-Bloushi, Shaima; Safer, Abdel-Majeed; Afzal, Mohammed; Mousa, Shaker A.
- Abstract
Reserpine, a natural product extracted from Rauwolfia serpintina or Rauwolfia vomitoria, is a known dopamine depicter that inhibits several neurotransmitters. Reserpine has been used clinically to control hypertension, schizophrenia, insomnia and insanity. The use of this drug, however, has been limited because of its side effects which include oxidative damage to organs, including the liver. Green tea catechins are potent antioxidants that have the potential to counteract reserpine induced oxidative stress. This study investigated the merits of administering green tea concurrently with reserpine to prevent oxidative hepatic damage in Spraguc-Dawely (SD) rats. Reserpine was found to cause hepatic damage, with elevated levels of oxidative stress markers, such as Thiobarbituric Acid Reactive Substances (TBARS), transaminases and cholesterol. Reserpine also induced hepatic ultra-structural damage in the cytoplasmic membrane, nuclear envelope, endoplasmin reticulum (rER), ribosomal stripping and mitochondria. Electron microscopy examination showed revival of liver cells as a result of green tea extract administration to experimental rats.
- Subjects
GREEN tea; RESERPINE; ANIMAL models in research; DOPAMINE; NEUROTRANSMITTERS; HYPERTENSION; SCHIZOPHRENIA; INSOMNIA
- Publication
Journal of Toxicological Sciences, 2009, Vol 34, Issue 1, p77
- ISSN
0388-1350
- Publication type
Article
- DOI
10.2131/jts.34.77