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- Title
Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii.
- Authors
Zheng-Xi Hu; Yong-Bo Xue; Xiao-Bin Bi; Jin-Wen Zhang; Zeng-Wei Luo; Xiao-Nian Li; Guang-Min Yao; Jian-Ping Wang; Yong-Hui Zhang
- Abstract
Five new compounds, including a benzopyran ribonic glycoside, daldiniside A (1), two isocoumarin ribonic glycosides, daldinisides B (2) and C (3), and two alkaloids, 1-(3-indolyl)-2R,3-dihydroxypropan-1-one (4) and 3-ethyl-2, 5-pyrazinedipropanoic acid (5), along with five known compounds (6-10), were isolated from the EtOAc extract of the marine-associated fungus, Daldinia eschscholzii. Their structures were elucidated by extensive physicochemical and spectroscopic properties, besides comparison with literature data. The absolute configurations of compounds 1-3 were corroborated by chemical transformation, GC analysis and X-ray crystallographic analysis. Meanwhile, the absolute configuration of compound 4 and the planar structure of compound 6 were also determined based on the X-ray diffraction analysis. The cytotoxicity of compounds 1-10, antifungal and anti-HIV activities of compounds 1-5 and the in vitro assay for glucose consumption of compounds 1-3 were done in the anti-diabetic model, whereas none showed obvious activity.
- Subjects
MARINE metabolites; MARINE fungi; BENZOPYRANS; GLYCOSIDES; ISOCOUMARINS; X-ray crystallography; X-ray diffraction
- Publication
Marine Drugs, 2014, Vol 12, Issue 11, p5563
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12115563