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- Title
Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus.
- Authors
Feng-Yu Du; Xiao-Ming Li; Peng Zhang; Chun-Shun Li; Bin-Gui Wang
- Abstract
Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4-7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
- Subjects
PEPTIDES; METABOLITES; BEAUVERIA; ENTOMOPATHOGENIC fungi; BIOLOGICAL assay; ANTI-infective agents; BRYOZOA; X-ray diffraction
- Publication
Marine Drugs, 2014, Vol 12, Issue 5, p2816
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12052816