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- Title
Prognostic Factors and Prediction of Survival for Patients with Brain Metastases of Lung Adenocarcinoma.
- Authors
Rongjiong Zheng; Dina Guo; Yongquan Dong; Mingming Wang; Meiling Hu; Yifeng Ren
- Abstract
Background: The study aimed to identify risk factors associated with overall survival (OS) of patients with lung adenocarcinoma (LACA) with brain metastasis and developed a prognostic tool (nomogram) for these patients. Methods: LACA patients with brain metastases between 2010 and 2013 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier analysis and a Cox regression model were used to assess the prognostic effect of variables on survival rate. A nomogram was developed to predict 3-, 6- and 9-month OS rates. Results: 2,631 LACA patients with brain metastases were studied. A nomogram was developed by using variables that affected OS and was validated by internal bootstrap resampling, which revealed that the nomogram had satisfactory discrimination. Conclusions: The nomogram was able to predict 3-, 6- and 9-month OS for patients with LACA and brain metastases.
- Subjects
OVERALL survival; BRAIN metastasis; PROGNOSIS; SURVIVAL rate; REGRESSION analysis
- Publication
Journal of Nippon Medical School, 2021, Vol 88, Issue 4, p319
- ISSN
1345-4676
- Publication type
Article
- DOI
10.1272/jnms.JNMS.2021_88-410