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- Title
Evaluation of a Percutaneously Controlled Hydraulic Occluder in a Rat Model of Gradual Venous Occlusion.
- Authors
Sereda, Colin W.; Adin, Christopher A.; Ginn, Pamela E.; Farese, James P.
- Abstract
To evaluate the efficacy of a percutaneously controlled hydraulic occluder (HO) in a rat model of gradual venous occlusion. Experimental study. Ten male Sprague–Dawley rats. HOs and perivascular transit time ultrasound flow probes were applied to the caudal vena cava (CVC). Occluders in group I rats (n=6) were gradually attenuated over 8 weeks, whereas occluders in group II rats (n=4) were not attenuated. Vena caval blood flow measurements were performed weekly in all rats for 8 weeks. After euthanasia, the CVC was evaluated grossly and by histopathology. Premature occlusion of the vena cava occurred during the 1st week in 3 rats (1 in group I, 2 in group II) because of kinking of the vena cava between the HO and the flow probe. For the remaining rats, mean blood flow in group I decreased significantly from 40.71 mL/min/kg at baseline to 4.68 mL/min/kg at 8 weeks ( P=.0094, power=0.91). Group II rats maintained vena caval blood flow at all times during the study. Complete occlusion of the vena cava was confirmed at necropsy in all group I rats. Gradual occlusion of the CVC of rats was achieved with HOs over 8 weeks. This model is limited by the size of the experimental animals and comparatively large implants. HOs may provide a method for gradual occlusion of congenital portosystemic shunts.
- Subjects
ARTERIAL occlusions; VENAE cavae; SURGICAL arteriovenous shunts; BLOOD flow; RATS
- Publication
Veterinary Surgery, 2005, Vol 34, Issue 1, p35
- ISSN
0161-3499
- Publication type
Article
- DOI
10.1111/j.1532-950x.2005.00006.x