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- Title
Pegylated Phosphine Ligands in Iridium(I) Catalyzed Hydrogen Isotope Exchange Reactions in Aqueous Buffers.
- Authors
Martinelli, Elisa; Spiller, Marie; Weck, Remo; Llompart, Pierre; Minoletti, Claire; Güssregen, Stefan; Sib, Anna; Derdau, Volker
- Abstract
The synthesis of a water‐soluble, phosphine‐pegylated iridium(I) catalyst and its application in hydrogen isotope exchange (HIE) reactions in buffer is reported. The longer polyethylene glycol side chains on the phosphine increased the water solubility independently from the pH. HIE reactions of polar substrates in protic solvents were studied. DFT calculations gave further insights into the catalytic processes. The scope and limitation of the pegylated catalyst was studied in HIE reactions of several complex compounds in borax buffer at pH 9 and the best conditions were applied in a tritium experiment with the drug telmisartan.
- Subjects
HYDROGEN isotopes; ISOTOPE exchange reactions; COMPLEX compounds; PROTOGENIC solvents; HOMOGENEOUS catalysis
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 48, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202402038