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- Title
Epithelial misplacement in Peutz–Jeghers polyps—the efficacy of the distribution of immunohistochemical markers in its diagnosis.
- Authors
Shepherd, Neil A; Wong, Newton A C S; Sheahan, Kieran
- Abstract
This article discusses the diagnostic difficulties associated with epithelial misplacement in Peutz-Jeghers polyps, a rare autosomal dominant gastrointestinal polyposis syndrome. The polyps are characterized by well-organized arborising muscular fibers lined by normal or hyperplastic mucosa. Epithelial misplacement, particularly in the small intestine, can mimic well-differentiated adenocarcinoma, leading to misdiagnosis. The article explores the use of immunohistochemical markers in differentiating non-neoplastic epithelium from neoplastic epithelium and emphasizes the importance of accurate diagnosis to prevent over-treatment.
- Subjects
INTESTINAL polyps; PEUTZ-Jeghers syndrome; GASTROINTESTINAL system; DIAGNOSTIC immunohistochemistry; INTESTINAL mucosa; ADENOMATOUS polyps
- Publication
Histopathology, 2024, Vol 85, Issue 4, p686
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.15293