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- Title
Depresyonlu Hastalarda Mirtazapin ve Venlafaxinin Serum BDNF Üzerine Etkisi.
- Authors
Özdemir, Gülay
- Abstract
Objective: In normal circumstances BDNF ensures a wide variety of brain neurones. However in stressful situations the BDNF gene is suppressed and this causes neural atrophy. This situation can lead to depression and the repeating of depressive episodes. In this way, neurotropic factors like BDNF which play a key role in the functioning of neurones result in a reduction of gene expression. The aim of this study is to compare the levels of BDNF in patients using venlafaxine and mirtazapine before treatment and two months after treatment. Method: Twenty six patients were selected fort his study. Eleven of the patients using mirtazapine were women and two were men. Twelve of the patients using venlafaxin were women and one was a man. In the control group there were ten women and one man. Beck Depression Scale, Beck Anxiety Scale were used to eveluate depression patients. Results: In each group no difference was found between BAÖ1, BAÖ2, BDÖ1, BDÖ2, BDNF1 and BDNF2. In the mirtazapine group differences were found between BAÖ1 and BAÖ2, BDÖ1 and BDÖ2 and BDNF1 and BDNF2. In the venlafaxine group differences were found between BAÖ1 and BAÖ2, BDÖ1 and BDÖ2 and BDNF1 and BDNF2. Conclusion: It was found that in each group the medicines had the same effect and that as anxiety and depression levels decreased the level of BDNF increased. At the start. in the control group the level of BDNF was 72.7% (positive) in the patient group the level was 20% (also positive) and this difference is statistically important. BDNF levels were found to be lower in the group diagnosed with depression.. These results are in line with current literature.
- Subjects
NEURONS; BRAIN-derived neurotrophic factor; VENLAFAXINE; ANTIDEPRESSANTS; GENE expression; MENTAL depression; ANXIETY disorders
- Publication
Klinik Psikofarmakoloji Bulteni, 2009, Vol 19, pS121
- ISSN
1017-7833
- Publication type
Article