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- Title
<sup>1</sup>H Quantitative NMR analyses of β-asarone and related compounds for quality control of Acorus rhizome herbal drugs in terms of the effects of their constituents on in vitro acetylcholine esterase activity.
- Authors
Lynn, Nwe Haymar; Linn, Thein Zaw; Yanmei, Cui; Shimozu, Yuuki; Taniguchi, Shoko; Hatano, Tsutomu
- Abstract
We used quantitative nuclear magnetic resonance analyses to measure the contents of major constituents of Acorus rhizome materials used as herbal drugs. The inhibitory effects of crude n-hexane extracts and their individual constituents on in vitro acetylcholine esterase activity were evaluated. The crude extracts had unexpectedly weak inhibitory effects (46–64% inhibition at 1.0 mg/mL), despite the high content (46–64%) of β-asarone, which independently had a potent effect (IC50 2.9 µM [0.61 µg/mL]). Further investigation revealed participation of eudesmin A, a lignan constituent, in the suppression of the inhibitory effect of β-asarone. 1H Quantitative NMR analyses of β-asarone and related compounds for quality control of Acorus rhizome herbal drugs in terms of the effects of their constituents on in vitro acetylcholine esterase activity
- Subjects
NUCLEAR magnetic resonance; QUALITY control; ACETYLCHOLINE
- Publication
Bioscience, Biotechnology & Biochemistry, 2019, Vol 83, Issue 5, p892
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2019.1569493