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- Title
Anti-inflammatory effects of Kaempferol on Helicobacter pylori-induced inflammation.
- Authors
Yeon, Min Ji; Lee, Min Ho; Kim, Do Hyun; Yang, Ji Yeong; Woo, Hyun Jun; Kwon, Hye Jin; Moon, Cheol; Kim, Sa-Hyun; Kim, Jong-Bae
- Abstract
Inflammation induced by Helicobacter pylori infection related to gastric carcinogenesis. In this study, we have investigated the anti-inflammatory effect and its mechanism of kaempferol in the inflammatory response caused by H. pylori infection in vitro. We found that kaempferol reduced the expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-8) and production of IL-8 in AGS cells. In addition, kaempferol suppressed translocation of cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA) of H. pylori to AGS cells. It was due to decreased transcription of type IV secretion system (T4SS) components involved in CagA injection and secretion system subunit protein A (SecA) of type V secretion system (T5SS) involved in VacA secretion by kaempferol. In conclusion, kaempferol shows the anti-inflammatory effect by suppressing the translocation of CagA and VacA proteins and leading to the down-regulation of pro-inflammatory cytokines. Abbreviations: CagA: cytotoxin-associated gene A; VacA: vacuolating cytotoxin A; T4SS: type IV secretion systems; SecA: secretion system subunit protein A; T5SS: type V secretion system;
- Subjects
HELICOBACTER pylori infections; ANTI-inflammatory agents; CYTOKINES
- Publication
Bioscience, Biotechnology & Biochemistry, 2019, Vol 83, Issue 1, p166
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2018.1528140