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- Title
A BODIPY‐Based Donor/Donor–Acceptor System: Towards Highly Efficient Long‐Wavelength‐Excitable Near‐IR Polymer Dots with Narrow and Strong Absorption Features.
- Authors
Chen, Lei; Chen, Dandan; Jiang, Yifei; Zhang, Jicheng; Yu, Jiangbo; DuFort, Christopher C.; Hingorani, Sunil R.; Zhang, Xuanjun; Wu, Changfeng; Chiu, Daniel T.
- Abstract
Bright long‐wavelength‐excitable semiconducting polymer dots (LWE‐Pdots) are highly desirable for in vivo imaging and multiplexed in vitro bioassays. LWE‐Pdots have been obtained by incorporating a near‐infrared (NIR) emitter into the backbone of a polymer host to develop a binary donor–acceptor (D–A) system. However, they usually suffer from severe concentration quenching and a trade‐off between fluorescence quantum yield (Φf) and absorption cross‐section (σ). Herein, we describe a ternary component (D1/D2–A) strategy to achieve ultrabright, green laser‐excitable Pdots with narrow‐band NIR emission by introducing a BODIPY‐based assistant polymer donor as D1. The D1/D2–A Pdots possess improved Φf and σ compared to corresponding binary D2–A Pdots. Their Φf is as high as 40.2 %, one of the most efficient NIR Pdots reported. The D1/D2–A Pdots show ultrahigh single‐particle brightness, 83‐fold brighter than Qdot 705 when excited by a 532 nm laser. When injected into mice, higher contrast in vivo tumor imaging was achieved using the ternary Pdots versus the binary D–A Pdots.
- Subjects
FLUORESCENCE yield; ORGANOBORON compounds; FLUORESCENT probes; CELL imaging; BIOFLUORESCENCE
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 21, p7082
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201902077