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- Title
Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules.
- Authors
Dong, Qian; Wang, Xuewei; Hu, Xiaoxiao; Xiao, Langqiu; Zhang, Liang; Song, Lijuan; Xu, Minglu; Zou, Yuxiu; Chen, Long; Chen, Zhuo; Tan, Weihong
- Abstract
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was developed to deliver enhanced PTT and simultaneously inhibit PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π-π interactions. Such AuNR@G-P-aspirin complexes were used for near-infrared laser-triggered photothermal ablation of solid tumor and simultaneous inhibition of PTT-induced inflammation through the release of aspirin in tumor milieu. This strategy showed excellent effects in vitro and in vivo.
- Subjects
GOLD nanoparticle synthesis; ANTI-inflammatory agents; CHEMICAL synthesis; PHOTOTHERAPY; PRODRUGS; PYRENE; ASPIRIN; GRAPHITE
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 1, p183
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201709648