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- Title
Ultrathin Cell-Membrane-Mimic Phosphorylcholine Polymer Film Coating Enables Large Improvements for In Vivo Electrochemical Detection.
- Authors
Liu, Xiaomeng; Xiao, Tongfang; Wu, Fei; Shen, Mo ‐ Yuan; Zhang, Meining; Yu, Hsiao ‐ hua; Mao, Lanqun
- Abstract
Resisting biomolecule adsorption onto the surface of brain-implanted microelectrodes is a key issue for in vivo monitoring of neurochemicals. Herein, we demonstrate that an ultrathin cell-membrane-mimic film of ethylenedioxythiophene tailored with zwitterionic phosphorylcholine (EDOT-PC) electropolymerized onto the surface of a carbon fiber microelectrode (CFE) not only resists protein adsorption but also maintains the sensitivity and time response for in vivo monitoring of dopamine (DA). As a consequence, the as-prepared PEDOT-PC/CFEs could be used as a new reliable platform for tracking DA in vivo and would help understand the physiological and pathological functions of DA.
- Subjects
CELL membranes; POLYMER films; ELECTROCHEMICAL analysis; BIOMOLECULES; DOPAMINE
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 39, p11964
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201705900