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- Title
Total Syntheses of Sarcandrolide J and Shizukaol D: Lindenane Sesquiterpenoid [4+2] Dimers.
- Authors
Yuan, Changchun; Du, Biao; Deng, Heping; Man, Yi; Liu, Bo
- Abstract
The syntheses of members of a family of lindenane sesquiterpenoid [4+2] dimers led to the total syntheses of sarcandrolide J and shizukaol D. Inspired by a modified biosynthetic pathway, a cascade featuring furan formation/alkene isomerization/Diels-Alder cycloaddition was devised to construct the congested polycyclic architecture of the target molecules with the correct stereochemistry. This study presents a pioneering synthetic entry to this family of natural products and paves the way for fully exploring their biological functions.
- Subjects
DIMERS; ALKENES; POLYCYCLIC compounds; DIELS-Alder reaction; RING formation (Chemistry)
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 2, p652
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201610484