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- Title
Investigation of biological activity and hyperthermia application of a quaternary magnetic nanobiocomposite based on functionalized carbon nitride nanosheets by carboxymethyl cellulose hydrogel and silk fibroin.
- Authors
Eivazzadeh-Keihan, Reza; Gorab, Mostafa Ghafori; Aliabadi, Hooman Aghamirza Moghim; Noruzi, Ehsan Bahojb; Kashtiaray, Amir; Bani, Milad Salimi; Etminan, Andisheh; Mirzahoseini, Hasan; Cohan, Reza Ahangari; Maleki, Ali; Mahdavi, Mohammad
- Abstract
Magnetic-responsive biopolymer composites have great potential for use in diverse biomedical applications. In this study, a new nanobiocomposite consisting of carbon nitride (CN), carboxymethyl cellulose (CMC) hydrogel, silk fibroin biopolymer, and magnetic iron oxide nanoparticles (Fe3O4 MNPs) was designed and fabricated. The synthesis procedure is based on the modification of the CN platform with CMC hydrogel and conjugation with SF biopolymer alongside in-situ magnetization with Fe3O4 MNPs. This hybrid magnetic nanobiocomposite was characterized by several analytical methods: FT-IR, EDX, SEM, XRD, TGA, and VSM. The in-vitro hemolysis assay confirmed the hemocompatibility of the prepared nanobiocomposite and its anticancer activity against breast cancer cell lines (BT549) was evaluated by MTT assay. Furthermore, the magnetic nanobiocomposite showed excellent potential for hyperthermia applications, with a maximum specific absorption rate of 7 W/g for 1 mg/mL of the sample under a magnetic field in different frequencies (100, 200, 300, and 400 MHz) and 5 to 20 min time intervals.
- Subjects
CARBOXYMETHYLCELLULOSE; SILK fibroin; IRON oxide nanoparticles; MAGNETICS; HYDROGELS; BIOPOLYMERS
- Publication
Cellulose, 2023, Vol 30, Issue 5, p2997
- ISSN
0969-0239
- Publication type
Article
- DOI
10.1007/s10570-023-05044-8