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- Title
The double-stranded microRNA precursor.
- Authors
Scarfiello, Elisabetta; Eichlinger, Julian; Meister, Gunter
- Abstract
MicroRNAs (miRNAs) are generated from stem-loop-structured double-stranded RNA precursors by the consecutive action of the two RNase III-type endoribonucleases Drosha and Dicer. However, such structures are very common on cellular transcripts and specific features have evolved that guide and regulate processing of stem-loop-structured hairpins into mature and functional miRNAs. These features include sequence motifs and local RNA structures but also trans-acting factors such as RNA binding proteins. The menu of features required for miRNA biogenesis is summarized in this review.
- Subjects
DOUBLE-stranded RNA; RNA-binding proteins; MICRORNA; ENDORIBONUCLEASES; RNA
- Publication
Advances in Biochemistry / Postepy Biochemii, 2024, Vol 70, Issue 1, p57
- ISSN
0032-5422
- Publication type
Article
- DOI
10.18388/pb.2021_522