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- Title
Green Synthesis of Novel Acridone Fused Tetracyclic Analogues via Microwave-Promoted Fast, Solvent-Free Benzylation and Their DFT Studies.
- Authors
Veligeti, Rajkumar; Anireddy, Jaya Shree; Madhu, Rajesh Bagepalli; Bendi, Anjaneyulu; Praveen, P. Laksmi; Jose, T. Jaison; Ramakrishna, D. S.
- Abstract
In this study, we introduce a new protocol for the synthesis of tetracyclic acridone derivatives using a benzylation reaction under microwave irradiation. Compared to traditional approaches, our protocol is significantly more effective, takes far less time and is also in accordance with the principles of green chemistry. Under the solvent-free conditions, the benzylation reaction was performed between acridone (1 eq) and benzyl bromide (1 eq) in the presence of potassium carbonate (1.5 eq) under microwave irradiation. The reaction was completed within 3 min, resulting in higher yields of the products, up to 96%. It has been observed that the developed protocol is best suited for the N-benzylation of acridone with different benzyl halides.
- Subjects
ORGANIC compounds; DENSITY functional theory; CHEMICAL derivatives; SUSTAINABLE chemistry; POTASSIUM carbonate
- Publication
Journal of Molecular & Engineering Materials, 2024, Vol 12, Issue 1/2, p1
- ISSN
2251-2373
- Publication type
Article
- DOI
10.1142/S2251237324400082