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- Title
α-Glucosidase Inhibitors from Polyscias serrata Roots in a Parallel Study of Network Pharmacology.
- Authors
Le Thi Tu Anh; Hoang Thai Dang; Nguyen Thi Thu Ha; Nguyen Thanh Tra; Nguyen Thi Thuy Linh; Ba Thi Cham; Bui Thi Thuy Luyen; Hoang Huy Do; Tiep Khac Nguyen
- Abstract
Nine triterpenoid saponins, one steroid and 4 simple phenolic compounds were isolated from the roots of P. serrata. All isolated compounds were examined for α- glucosidase inhibition effects. The simple phenolics 4-Hydroxy-4-methoxy-benzoic acid (7) and Protocatechuic acid (9) showed the greatest inhibition effects among the isolated compounds with IC50 values of 0.55 ± 0.01 and 0.84 ± 0.02 μg/mL, respectively. Network pharmacology approach was applied to investigate the molecular mechanisms of α- glucosidase inhibition activities of isolated compounds. In light of the data obtained in this study, it is evaluated that the insulin resistance pathway may be the primary mechanism of action.
- Subjects
TRITERPENOID saponins; PHARMACOLOGY; INSULIN resistance; ALPHA-glucosidases; SAPONINS; PHENOLS; MOLECULAR docking; PLANT phenols
- Publication
Records of Natural Products, 2024, Vol 18, Issue 3, p363
- ISSN
1307-6167
- Publication type
Article
- DOI
10.25135/rnp.457.2401.3038