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- Title
Follow-up outcomes of pediatric patients who underwent surgical resection for lipoblastomas or lipoblastomatosis: a single-institution experience with a systematic review and meta-analysis.
- Authors
Dao, Dyda; Najor, Anna J.; Sun, Philip Y.; Farrokhyar, Forough; Moir, Christopher R.; Ishitani, Michael B.
- Abstract
<bold>Purpose: </bold>The objective of this study was to examine the long-term outcomes of pediatric patients who underwent surgical resection for lipoblastoma and lipoblastomatosis (LB/LBM).<bold>Methods: </bold>A single-center retrospective study of pediatric patients with LB/LBMs seen between 1991 and 2015 was conducted. A systematic review, including studies published prior to late August 2018, was performed. Using a random effect meta-analysis, pooled weighted proportions and unadjusted odds ratios (OR) with 95% confidence intervals (CI) were calculated.<bold>Results: </bold>The retrospective study included 16 patients, while the systematic review included 19 published studies consisting of 381 patients. Among 329 (82%) patients with follow-up information, the pooled recurrence rate was 16.8% (95% CI 10.9-23.5%; I2 = 59%). The reported time to recurrence ranged from < 1 to 8 years. Recurrence risk was greater for incomplete (n = 34) than complete resection (n = 150): OR 11.4 (95% CI 3.0-43.6; I2 = 43%). LBMs (n = 35) had a greater recurrence risk than LBs (n = 116): OR 5.5 (95% CI 1.9-15.9; I2 = 0%). Recurrences were higher for studies with approximately ≥ 3 years of follow-up versus studies with < 3 years of follow-up.<bold>Conclusion: </bold>Recurrences are more likely to occur with LBMs and/or incomplete resection. Follow-up beyond 3-5 years should be considered given that the recurrence risk appears to be greater in the long-term.
- Subjects
SURGICAL excision; META-analysis; ODDS ratio; RETROSPECTIVE studies; CONFIDENCE intervals; RESEARCH; OPERATIVE surgery; TIME; RESEARCH methodology; SYSTEMATIC reviews; EVALUATION research; MEDICAL cooperation; SOFT tissue tumors; TREATMENT effectiveness; COMPARATIVE studies; LIPOSARCOMA; LONGITUDINAL method
- Publication
Pediatric Surgery International, 2020, Vol 36, Issue 3, p341
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-019-04612-z