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- Title
COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.
- Authors
Regalla, Dinesh; VanNatta, Mollie; Alam, Mohammad; Malek, Alexandre E.
- Abstract
Background: Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described. Methods: We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection. Results: We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis. Conclusion: In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.
- Subjects
OPPORTUNISTIC infections; INTENSIVE care units; COVID-19; ADRENOCORTICAL hormones; CRYPTOCOCCOSIS; CRITICALLY ill; IMMUNOSUPPRESSION; PATIENTS; FUNGAL lung diseases; SEVERITY of illness index; HOSPITAL admission &; discharge; RISK assessment; CRYPTOCOCCUS neoformans; MENINGITIS; DISEASE risk factors
- Publication
Infection, 2022, Vol 50, Issue 4, p1007
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-022-01805-y